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Endocrine Physiology · NBME-Style

Endocrine Physiology — NBME-style practice question

A physician-validated, board-style question from the Active Transport QBank. Try it, then check the reasoning for every option.

A 70-year-old woman, gravida 5, para 5, comes to the physician for the evaluation of sensation of vaginal fullness for the last six months. During this period, she has had lower back and pelvic pain that is worse with prolonged standing or walking. The patient underwent a hysterectomy at the age of 35 years because of severe dysmenorrhea. She has type 2 diabetes mellitus and hypercholesterolemia. Medications include metformin and atorvastatin. Vital signs are within normal limits. Pelvic examination elicits a feeling of pressure on the perineum. Pelvic floor muscle and anal sphincter tone are decreased. Pelvic examination shows protrusion of posterior vaginal wall with Valsalva maneuver and vaginal discharge. Which of the following is the most likely diagnosis?

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Answer: D. Pelvic organ prolapse in a multiparous postmenopausal woman with a history of hysterectomy presents as a sensation of vaginal fullness, pelvic pressure worse with prolonged standing, and visible protrusion of vaginal walls on Valsalva. The protruding compartment determines the type of prolapse: - ANTERIOR wall protrusion = cystocele (bladder). - POSTERIOR wall protrusion can be a rectocele (rectum) OR an enterocele (small bowel/peritoneum). - APICAL = uterine prolapse (or vaginal vault prolapse in post-hysterectomy patients). The patient had a hysterectomy 30+ years ago, which removed the natural apical support. The posterior vaginal wall protrusion in this setting is most often an ENTEROCELE — herniation of the cul-de-sac peritoneum and small bowel through the weakened upper posterior vaginal wall. Enteroceles are particularly common in post-hysterectomy women because the vaginal cuff loses its uterosacral ligament support. Management options range from pelvic floor physical therapy and pessaries (conservative) to surgical repair (sacrocolpopexy, vaginal suspension procedures). Risk factors include vaginal parity, age, menopause, prior hysterectomy, obesity, and chronic increased intra-abdominal pressure. **Why each option:** **A.** Bartholin gland cysts present as a fluctuant mass at the posterior vaginal introitus (4 or 8 o'clock position), not as a wall protrusion with Valsalva. **B.** Atrophic vaginitis (postmenopausal) presents with dryness, dyspareunia, and thin pale mucosa — not pelvic pressure with Valsalva-induced wall protrusion. **C.** Infectious vulvovaginitis presents with discharge, itching, erythema — and doesn't cause a protruding bulge. **D.** Enterocele (herniation of peritoneum/small bowel through posterior vaginal wall) is classic in post-hysterectomy women with apical/posterior wall protrusion on Valsalva.

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