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Question 1 of 25 · NBME-Style

A 22-year-old man is brought to the ED 30 minutes after a stab wound to the left fifth intercostal space. Pulse 128/min, BP 78/50 mmHg. Neck veins are distended, heart sounds are distant. ECG shows electrical alternans and low voltage. Bedside echo reveals a large pericardial effusion with right ventricular diastolic collapse. Which of the following hemodynamic findings is most likely present?

  • A. Increased left ventricular end-diastolic volume
  • B. Equalization of diastolic pressures across all four chambers
  • C. Decreased systemic vascular resistance
  • D. Widened pulse pressure with bounding peripheral pulses
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Features

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NBME-Style Questions

Multi-step clinical vignettes with realistic distractors, written using few-shot prompting on real Step exam patterns.

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Sample question

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A real NBME-style question generated from a paragraph of cardiology notes.

Difficulty: NBME-Style

A 58-year-old man with a 30-pack-year smoking history and chronic productive cough is brought to the ED after an episode of syncope. Temperature 37.1°C, pulse 88/min, BP 95/60 mmHg. Physical examination shows facial plethora, jugular venous distension that does not vary with respiration, and bilateral upper extremity edema. Chest CT reveals a large central mass encasing the mediastinal vasculature. Serum sodium is 128 mEq/L and serum osmolality is 268 mOsm/kg. Which of the following is the most likely cause of this patient's hyponatremia?

  • A. Decreased aldosterone secretion from adrenal metastases
  • B. Renal sodium wasting from cisplatin nephrotoxicity
  • C. Ectopic antidiuretic hormone secretion by tumor cells
  • D. Psychogenic polydipsia from corticosteroid therapy
  • E. Cerebral salt wasting from brain metastatic disease
Why C: Three steps — recognize SVC syndrome + central mass = small cell lung carcinoma, connect SCLC to paraneoplastic syndromes, identify SIADH as the cause of euvolemic hyponatremia. The distractors each represent a real cause of hyponatremia in cancer patients but are ruled out by specific vignette details.
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FAQ

Frequently asked questions

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Is this a replacement for UWorld?

No — UWorld remains the gold standard for graded prep. Active Transport is best as a supplement: turn your own lecture notes and Brick decks into custom practice so you can drill the material your school actually tests on.

How accurate are the AI-generated questions?

We use GPT-4o with few-shot NBME prompting and extensive answer validation. Quality is high, but no AI is perfect — always cross-reference with authoritative sources. The community QBank surfaces top-rated questions over time.

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⚠️ Educational use only. Active Transport generates AI-based study material and is not medical advice. Always verify clinical content against authoritative sources. Not affiliated with NBME, UWorld, or AMBOSS.